Characteristics of the VEGF-dependent mechanism where impaired angiogenesis and cardiac vascular permeability occur in mice exhibiting metabolic syndrome features

Symbol
1M15
Rok początku realizacji
2019
Konkurs/program
DIAMENTOWY GRANT
Kierownik
Krzysztof Bartkowiak
Numer umowy o dofinansowanie
0200/DIA/2019/48
Przyznane środki ogółem TYLKO WUM
220 000,00
Przyznane środki ogółem NA WSZYSTKICH
220 000,00
Cel projektu

The research will help to broaden the understanding of the influence of the metabolic syndrome on the dysfunction of the endothelium of the heart blood vessels and to explain the mechanism of VEGF's autocrine action, which leads to impaired blood vessel formation and increased microvascular permeability in the heart. The isolated endothelial cells of the blood vessels of the heart of mice with metabolic syndrome, on which the research will be conducted, will allow to precisely determine the role these cells play in the pathogenesis of heart failure observed in this disease.