Zastosowanie zintegrowanej transkryptomiki jako narzędzia do wczesnej diagnostyki, prognozowania i monitorowania leczenia u pacjentów z trądzikiem odwróconym (hidradenitis suppurativa)

The aim of this research project is:
1) To characterize the specific patient’s profiles in HS disease by miRNAs assessment using in silico
prediction analysis, and thereafter validation.
2) To compare the impact of different treatment regimens (antibiotics vs TNFα inhibitors) on the change
in expression of miRNAs (selected by bioinformatic analysis) associated with pathological processes such as
inflammation, autophagy, oxidative stress and fibrosis in HS patients.
3) Analysis of the association between: (i) changes in the expression of specific miRNAs and (ii) markers of
inflammation, autophagy, oxidative stress, fibrosis processes and (iii) clinical manifestations of HS
(distribution, advancement, number and severity of skin lesions).
4) Evaluation of the usefulness of the obtained results in clinical practice, construction of a dedicated scale
combining evaluation of miRNAs expression, standard parameters of inflammation, autophagy, oxidative
stress, fibrosis and ultrasound features in order to monitor and evaluate clinical efficacy of treatment in a
selected drug regimen.