The role of indole in the regulation of blood pressure and the pathogenesis of arterial hypertension

Recent studies indicate that the pathogenesis of arterial hypertension may be related to disturbances in the composition of the intestinal flora. The commensal colonizing bacteria in the gut metabolize nutrients to produce a range of compounds that enter the bloodstream. The aim of the proposed project is to study the role of indole, a metabolite of intestinal bacteria, in the regulation of blood pressure and the development of hypertension. Haemodynamic studies will be performed in normotensive animals (WKY rats), hypertensive animals (SHR rats) and rats with borderline arterial pressure (BHR rats). The effect of increased indole levels in the large intestine, peripheral blood and cerebrospinal fluid on the regulation of blood pressure and the development of hypertension will be investigated. In addition, possible mechanisms by which indole could act in the body will be explored. Hypertension and its complications are one of the main causes of morbidity and mortality in Poland and the EU. The results of the proposed study may contribute to understanding the role of indole, a metabolite of the intestinal flora, in the regulation of blood pressure and in the pathogenesis of hypertension. The study will assess the therapeutic potential of indole synthesis donors / inhibitors in cardiovascular diseases, especially in arterial hypertension.