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Investigation of the mechanisms of venetoclax resistance and methods of combating it in B-cell acute lymphoblastic leukemia with rearrangements of the MLL gene

Project Title
Zbadanie mechanizmów oporności na wenetoklaks i sposobów jej zwalczania w ostrej białaczce limfoblastycznej B komórkowej z rearanżacjami genu MLL
Financing Institution
Lead
mgr inż. Klaudyna Fidyt
Project Objective

Acute B-cell lymphoblastic leukemia (ALL) is a genetically differentiated cancer of the haematopoietic system. This type of leukemia is most common in children, but it can also affect adults. In recent years, the effectiveness of the treatment of ALL has significantly improved, but the best treatment effects are mainly observed in children. Unfortunately, not all ALL subtypes respond to standard chemotherapy treatments. One of the subtypes with a particularly poor prognosis is ALL with MIL gene rearrangement (MLLr ALL). The incidence of this particular subtype of ALL mainly affects infants, less often adolescents, but in the elderly the risk of developing the disease increases with age. Given the poor response to chemotherapeutic agents and the qualification of MLLr ALL to a high-risk group, it is necessary to search for new, targeted therapies to improve treatment outcomes.