Investigation of the role of regulatory lymphocytes and indoleamine 2.3-dioxygenase in the progression and shaping of the immunosuppressive microenvironment of chronic lymphocytic leukemia
Project Title
Zbadanie roli limfocytów regulatorowych i 2,3-dioksygenazy indoloaminy w progresji i kształtowaniu immunosupresyjnego mikrośrodowiska przewlekłej białaczki limfocytowej
Financing Institution
Lead
dr Angelika Muchowicz
Project Objective
In this project, we will investigate the role of Treg and IDO in CLL using a mouse model of the disease that very well reflects the immune system dysfunction observed in CLL patients. We want to answer the following questions: (1) do Treg lymphocytes influence leukemia progression? (2) how does the elimination of Treg lymphocytes affect the number and function of effector T lymphocytes and antigen presenting cells? (3) what is the role of IDO in Treg cell accumulation during leukemia progression?, (4) does IDO affect leukemia progression? (5) whether and how inhibition of IDO affects the functions of other cells of the immune system?