The objective of the project is to develop an international consensus and procedure algorithm in cooperation with the experts of the Immunology Section Working Group of the European Academy of Allergology and Clinical Immunology (EAACI). In EAACI, there was appointed a 23-person international Working Group which, under this project, will perform regular checks, data analysis and will clarify the immunological mechanisms in MIS-C. The group will subsequently propose a clinical algorithm for the diagnostics and treatment of severe MIS-C, based on the cooperation between the basic sciences and clinicians from 11 countries. We will propose an international strategy for the understanding of the MIS-C mechanisms, diagnostics and procedure.
At the same time, under the project, we are planning to do research into the populations of virus-specific lymphocytic cells in mucosa samples taken non-invasively from MIS-C patients’ nasal cavities and shifts within those populations in the inflamattory tissues in acute phase of MIS-C and in health. The samples of nasal mucosa will be taken from 20 patients in Warsaw and Rotterdam in autumn 2021. At the University Medical Centre in Leiden there will be conducted mass cytometry and analysis of cell populations in affected tissues as well as investigation of their correlations with the PIMS/MIS-C clinic. This research will provide a unique insight into the dynamics and the gist of immunological phenomena in MIS-C mucosa.
Franciscus Gasthuis & Vlietland Teaching Hospital and Leiden University Medical Centre.