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  2. Determination of new functional variants within genes related to the platelet activation pathways and assessment of their impact on the risk of ischemic stroke in the Polish population

Determination of new functional variants within genes related to the platelet activation pathways and assessment of their impact on the risk of ischemic stroke in the Polish population

Project Title
Określenie nowych funkcjonalnych wariantów w obrębie genów związany ze szlakami aktywacji płytek krwi oraz ocena ich wpływu na ryzyko wystąpienia udaru niedokrwiennego mózgu w populacji polskiej.
Financing Institution
Lead
dr hab. Marek Postuła
Project Objective

1. Identification of new, rare and functional genetic variants within genes related to the process of activation and aggregation of platelets in the Polish population with a history of ischemic stroke. 2. Compared carriers of rare functional variants within individual genes (potentially harmful) in the study group and the control group (without a history of ischemic stroke) in order to determine their relationship with the risk of stroke. 3. Assessment of the relationship between the presence of rare functional variants and short-term prognosis based on the assessment of neurological disorders in patients after ischemic stroke. 4. Functional studies of genes based on the use of in vitro cell culture as an experimental model to confirm changes in protein activity at the cellular level.