Assessment of the immunomodulatory effect of cefazolin as a potential inhibitor of pro-inflammatory cytokines binding to the gamma receptor (CD132) in the treatment of autoimmune diseases

The γc receptor (CD132) is a subunit of interleukin (IL) 2, 4, 7, 9, 15 and 21 receptors. Too high activation of γc leads to an excessive immune response and may lead to the development of autoimmune diseases. The binding of a ligand to the γc receptor leads to the phosphorylation of JAK1 and JAK3 Janus kinases, followed by signal transduction to the nucleus and activation of gene expression. In recent years, research has been conducted into the possible use of JAK1 and JAK3 kinase inhibitors in the treatment of autoimmune diseases. The aim of the research planned in this project is to investigate whether cefazolin, a cephalosporin antibiotic, inhibits γc receptor activation.