The use of high-volume thoracentesis and pleural pressure measurement to study the newly described pathophysiological phenomena in patients with pleural fluid
opłucnowego do badania nowo opisanych zjawisk patofizjologicznych u chorych z płynem w
jamie opłucnej
opłucnowego do badania nowo opisanych zjawisk patofizjologicznych u chorych z płynem w
jamie opłucnej
The objectives of the project
Objective 1. To study whether voluntary cough and/or CPAP facilitate the recruitment of atelectatic
lung regions and elevation of Ppl in patients undergoing TT.
Objective 2. To assess the percentage of patients in whom TT is associated with a decline in blood
oxygenation and whether this decline is caused by increased V/Q mismatch and pulmonary shunt.
Objective 3. To evaluate whether mediastinum and diaphragm compliance and the anatomical shift of these structures have a significant impact on the pattern of Ppl fall
Objective 4. To study PPP and its changes in terms of the relationship with systolic and diastolic heart
volume and the changes in stroke volume.
Objective 5. To evaluate whether large volume PE impairs function of the respiratory muscles and
whether impaired function of inspiratory muscles is associated with the sensation of the breathlessness.
The positive results may be a prerequisite for changing the recommendations on TT in the future (e.g. encouragement to cough or CPAP application during and after the procedur )
The results may also encourage a more thorough rehabilitation of patients with pleural effusion to decrease muscle weakness and sensation of breathlessness. The results of this study may shed a new light on the understanding of the mechanisms responsible for the components of Pel different than lung expandability.