MicroRNA profiling in pre-neoplastic lesions and early laryngeal cancer
The aim of the project is to identify the deregulated miRNA at early stages of larynx carcinogenesis. Determination of the processes accompanying the transformation of larynx hypertrophic changes into dysplastic changes and invasive larynx cancer is necessary to obtain knowledge about factors determining individual stages of carcinogenesis in larynx cancer. Identification of molecular mechanisms responsible for larynx cancer progression at early stages of dysplasia and malignant transformation may in the future constitute a basis for developing different methods of personalised therapy to prevent and/or suppress the laryngeal cancer progression. The proposed study is an introduction to the planned project, encompassing a wide assessment of the miRNA expression profile in dysplastic changes and in early phase of laryngeal cancer in order to identify the important markers related to the histopathological stadium of carcinogenesis, financed from the funds obtained under OPUS or Sonata BIS programmes.