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Effect of ibuprofen on the immunomodulatory and regenerative potential of human mesenchymal stromal cells in the bone marrow

Project Title
Wpływ ibuprofenu na potencjał immunomodulacyjny i regeneracyjny ludzkich mezenchymalnych komórek zrębu szpiku kostnego.
Financing Institution
Lead
mgr Agnieszka Kulesza
Project Objective

The experiments will be conducted with the use of human bone marrow derived MSCs. The effect of ibuprofen on MSC cells will be analyzed by comparing the MSCs cultured in the presence of ibuprofen (test samples) to the control samples (MSC cultured under standard conditions). For this purpose, a series of tests will be carried out, which will allow to identify genes and proteins, the expression of which changes under the influence of the drug we use. An experiment will also be performed in which MSC cells will be cultured together with macrophages (cells of the immune system responsible for "eating" of microorganisms that have penetrated into our body and also take part in regenerative processes). Thanks to this, it will be possible to determine if and how ibuprofen influences the interactions between the two populations of cells.