The role of reactive nitrogen forms in the formation of extracellular neutrophilic networks.

The aim of the project is to investigate the project to investigate the role of reactive nitrogen species in the formation of NETs, ​​including the mechanism underlying the formation of RFA-induced NETs, ​​and to check whether their participation is necessary for this process. Expected results The formation of extracellular neutrophilic networks has been discovered relatively recently, and although this process has been the subject of much scientific research, our knowledge of the regulation and course of this phenomenon remains incomplete. The research carried out in this project will provide a better understanding of the mechanisms of non-specific immune responses as well as our understanding of the modulating role of RFA in the functioning of cells of the immune system. It is worth noting, however, that detailed research on the factors responsible for the regulation and course of the phenomenon of networking is interesting not only because of the progress in science. In the future, they could have an impact on clinical medicine, pointing to new treatment strategies for many inflammatory and autoimmune diseases where excessive networking is involved in pathogenesis.