Overperceptualizaction in schizophrenia - from basic research to cognitive interventions

With regard to the most important publications, research achievements carried out with the team of prof. Dr hab. Mariusz Ratajczak shed new light on the phenomenon of mobilization, implantation and retention of hematopoietic stem cells (KMM). The results obtained in the study indicate a significant role of the lectin activation pathway of the complement cascade in relation to the phenomenon of pharmacological mobilization, suggesting the potential use of mannose-binding lectin determination in determining the mobilization capacity of the organism. The conducted studies have also shown the inhibitory effect of heme oxygenase (HO-1) on the chemotactic activity of KKM, while enhancing their adhesive properties, making the HO-1 inhibitor a potential tool to improve the treatment of diseases using KKM transplants in patients. Moreover, the role of TLR signaling together with the MyD88 protein (myeloid differentiation primary response) has been shown to enhance HO-1 expression in these cells, which negatively affects the process of their exit from the marrow niche to peripheral blood. For the first time, our research has also shown the participation of the Apolytic enzyme, ie phospholipase C (PLC-B2), in the pharmacologically induced KKM mobilization, in addition to proteolytic enzymes. In addition, the results published in the study demonstrate the role of sphingosine-1 phosphate (S1P) in the bone marrow microenvironment, confirming the concept of the presence of other SDF-1-CXCR4 axes that are involved in implantation, colonization of the marrow niche and retention of hematopoietic stem cells. The results obtained with my participation may contribute to the effective therapy of hematological diseases, the treatment of which is hematopoietic stem cell transplantation.