The role of tumor necrosis factor (TNF) in the regulation of pain response
Project Title
Rola czynnika martwicy nowotworów (TNF) w regulacji reakcji bólowej.
Financing Institution
Lead
dr hab. Ewa Bałkowiec-Iskra
Project Objective
The research hypothesis of the project assumes that the production of two key mediators in the trigeminal system - the calcitonin gene derivative peptide (CGRP) and the cerebral neurotrophic factor (BDNF) depends on the activity of neurons and the presence of inflammatory factors. The aim of the project is to investigate the role of the pro-inflammatory cytokine - tumor necrosis factor (TNF) in modulating the function of sensory neurons in the trigeminal ganglion.