Participation of intestinal bacteria and methylamines derived from the intestinal microflora in the regulation of blood pressure and the development of arterial hypertension

The aim of the study is to find out the influence of intestinal bacteria and the methylamines they produce on the development of arterial hypertension. Recent studies indicate that arterial hypertension may be associated with disturbances in the composition of the intestinal flora. The effect of gut bacteria on the functioning of the circulatory system can take place through a number of chemicals produced by the gut microflora that enter the bloodstream. More and more studies suggest that methylamines produced by intestinal bacteria may play an important role in the pathogenesis of cardiovascular disease. It has been shown that an increase in the concentration of trimethylamine oxide in the blood is associated with a higher risk of myocardial infarction, stroke and death. In the proposed project, tests will be carried out on rats fed with water or water containing the tested methylamines. The effect of methylamines on blood pressure and heart function will be investigated. Hypertension and its complications are one of the most important causes of death and disability. The proposed project aims to investigate new compounds that may be responsible for the development of hypertension. The results of the study may contribute to the creation of a new group of drugs for arterial hypertension, the mechanism of action of which will be based on the modification of the production of methylamines in the human intestines.